Off-Target Biology and Genomics Scientist - Gene Therapy

• Lead and execute genomic safety assessment packages for gene editing therapeutics, spanning off-target discovery, verification/validation, and genomic integrity characterization.
• Apply and evaluate a range of off-target discovery approaches, including in silico tools (CALITAS, CRISPRMe, CasOFFinder), biochemical methods (SITE-seq, CIRCLE-seq, CHANGE-seq, Digenome-seq), and cell-based assays (GUIDE-seq, INDUCE-seq).
• Drive off-target verification and validation using amplicon-based sequencing approaches such as AmpSeq, rhAmpSeq, and hybrid capture sequencing.
• Characterize genomic integrity using orthogonal methods including karyotyping, optical genome mapping, and WGS.
• Assess genotoxicity potential of next-generation genome engineering modalities (base editors, prime editors) using modality-appropriate off-target assessment strategies.
• Contribute to or lead novel assay development efforts to interrogate emerging genome editing modalities (Gen 5+)
• Integrate biodistribution data to guide tissue selection for off-target verification studies

Minimum Required Qualifications:

• B.S. in genomics, molecular biology, biochemistry, or a related field with 5+ years of industry experience in off-target assessment and/or genomic safety evaluation for gene editing therapeutics. M.S. in genomics, molecular biology, biochemistry, or a related field with 3-7 years of industry experience in off-target assessment and/or genomic safety evaluation for gene editing therapeutics. Ph.D. in genomics, molecular biology, biochemistry or related field with 2-4 years of industry experience in off-target assessment and/or genomic safety evaluation for gene editing therapeutics.
• Proficiency with CRISPR-based genome editing and familiarity with a broad range of off-target discovery platforms.
• Experience with next-generation sequencing workflows and data interpretation.
• Familiarity with emerging modalities such as base editing and prime editing, and their associated genotoxicity considerations.
• Strong track record of scientific problem-solving, with experience in assay development being a plus.
• Excellent written and verbal communication skills; ability to present complex data to cross-functional teams.
• Ability to work independently and as a part of a team, self-motivation, adaptability, and a positive attitude.

Preferred Qualifications:

• Experience with optical genome mapping (Bionano platform).
• Familiarity with regulatory expectations around genomic safety packages for IND/BLA submissions.
• Experience with human diversity-dependent off-target discovery approaches (e.g., ONE-seq).
• Authorization to work in the United States indefinitely without restriction or sponsorship.

 

The position is Full Time, Monday-Friday, 8 am-5 pm. Candidates currently living within a commutable distance of Boston, MA, are encouraged to apply

What to Expect in the Hiring Process:

• 10-15 Minute Phone Interview with Regional Recruiter
• 45-60 Minute Virtual Interview with Manager and/or Group Leader
• 45-60 Minute In-Person Meeting for a Casual Discussion of the Role

What We Offer:

• Excellent full-time benefits, including comprehensive medical coverage, dental, and vision options
• Life and disability insurance
• 401(k) with company match
• Paid vacation and holidays
• Yearly goal-based bonus & eligibility for merit-based increases
• Annual Compensation is $104,000 - $112,320, depending on education and experience 

Eurofins USA PSS Insourcing Solutions is a Disabled and Veteran Equal Employment Opportunity employer.