Senior AI Engineer

Sequencing is building the interface between humanity and its DNA.

Using clinical-grade whole genome sequencing, AI, and a rapidly expanding ecosystem of genomic applications, we help people better understand themselves, their health, and their future through their DNA.

The human genome is one of the most valuable and underutilized resources in the world. Our mission is to transform the human genome into a lifelong source of personalized guidance and build the trusted home for every genome on Earth.

As the world’s largest direct-to-consumer whole genome sequencing platform, Sequencing is helping define the future of AI-powered personalized health.

We’re a profitable, venture-backed, fully remote company building category-defining products that help people better understand themselves through their DNA.

The opportunity

As a Senior AI Engineer you build and improve the AI agent systems that power personalized genetics based health guidance. You work side by side with our AI Backend Architect to move from simple large language model calls to a true multi agent brain that plans routes and checks every answer. When you do this well, people can have meaningful conversations with their DNA and receive trustworthy guidance that evolves alongside advances in science and AI.

What you'll own

• Design and improve multi agent AI systems where planner orchestrator worker and evaluator agents work together on each request.
• Build planner and router agents that decide which worker agent Genome Research Health or Drug should handle each task.
• Create AI agents that can pick use and chain tools on their own including ReAct style agents that can write and run code in a safe loop.
• Set up clear interfaces and parallel execution for worker agents so answers stay fast even as we add more data and tools.
• Build critic and review layers that check responses for quality safety and scientific accuracy before sending them to the user.
• Reduce wait times by running agents in parallel precaching likely intents and making tool calls and data access as efficient as possible.
• Build and maintain evaluation pipelines and benchmarks so we can measure answer quality response speed and reliability over time.
• Design and run production AI backend services in TypeScript that connect agents to genomics and health data.
• Design and evolve persistent memory, personalization, and learning systems that allow AI experiences to become more useful over time while maintaining privacy and security.
• Build prompt flows retrieval pipelines and guardrails so models stay grounded in real genetic and health evidence not guesses.
• Integrate and run databases queues and data systems such as PostgreSQL MySQL AWS SQS Redis BullMQ and AWS Glue in the AI backend.
• Support backend systems that power native mobile apps so experiences feel fast and stable on every device.
• Work closely with bioinformatics teammates to be sure AI answers match what the DNA and science actually say.
• Partner with product and design to make AI answers feel simple caring and easy to act on for non experts.
• Help shape a self improving AI system that can learn from patterns across many users while keeping their data private and secure.

Who you are

• 5+ years building and operating production software systems, including AI-powered or data-intensive applications at scale.
• Expert with TypeScript and comfortable owning production backend services.
• Proven experience building multi agent AI systems and orchestration patterns not just wiring up a single large language model.
• Deep hands on work with large language model APIs such as Anthropic OpenAI Bedrock DeepSeek or Google AI in real products.
• Experience creating high-quality evaluation datasets and golden Q&A sets for LLMs, including workflows that involve domain expert review for accuracy.
• Practical experience preparing data for fine-tuning or distillation. Understanding when these techniques add real value versus improving RAG, prompting, or tool design.
• Experience building structured retrieval augmented generation pipelines and retrieval systems.
• Experience with hierarchical agent designs planner and orchestrator patterns dynamic tool use and autonomous agents.
• Experience building evaluation pipelines benchmarks and response quality scoring plus tuning systems for low latency.
• Experience with PostgreSQL DuckDB Apache Spark and service oriented architectures.
• Strong understanding of how to speed up AI systems using parallel execution caching and efficient tool calls.
• Familiarity with services like AWS SageMaker for model training and customization alongside Bedrock.
• Strong intuition for where AI systems are headed over the next three years and excitement for turning emerging capabilities into real-world products.
• Able to work independently in a remote setup while partnering closely with product engineering and bioinformatics.
• Customer obsessed and quality driven with a strong respect for scientific accuracy and safety around health.
• Nice to have familiarity with genomics bioinformatics or health data systems agent frameworks like LangGraph AutoGen or CrewAI self improving agent loops startup environments or Rust.

Why this matters

AI is transforming how people access information. Genomics is transforming how people understand themselves.

This role sits at the convergence of both.

You’ll help build the AI systems that enable people to interact with their DNA and receive personalized guidance throughout their lives. The systems you build will help millions of people better understand their health, identify risks earlier, make more informed decisions, and benefit from advances in science that would otherwise remain inaccessible.

This is an opportunity to help create a category-defining, generational product and shape how humanity interacts with its DNA for decades to come.

Benefits Overview

• Comprehensive medical, dental, and vision insurance coverage
• 401(k) with company matching
• Paid time off (PTO)
• Paid volunteer time off
• Fully remote work with home office stipend
• Parental bonding leave
• Clinical-grade whole genome sequencing for you and your family (private and confidential)

Join Sequencing

• Redefine how people understand themselves through their DNA
• Build category-defining products alongside scientists, engineers, and innovators
• Contribute to technology that will improve and extend millions of lives
• Shape one of the most important emerging categories in AI and healthcare

Sequencing Inc. is an equal opportunity employer. All aspects of employment, including the decision to hire, promote, discipline, or discharge, will be based on merit, competence, performance, and business needs. We do not discriminate based on race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical condition, pregnancy, genetic information, gender, sexual orientation, gender identity or expression, veteran status, or any other status protected under federal, state, or local law.

Sequencing Inc. may use artificial intelligence (AI) or automated tools as part of the recruiting and hiring process, including for application screening and candidate evaluation. These tools may analyze information provided in your application materials or during the hiring process. Where required by applicable law, candidates may request a reasonable accommodation or an alternative selection process by contacting joinus@sequencing.com .