global-channel-managementinc
Biochemist Biophysicist
Job description
Biochemist Biophysicist needs 2+ years hands-on experience in biophysics, bioconjugation, protein labeling, or a combination thereof.
Biochemist Biophysicist requires
BS, MS, or PhD in Biochemistry, Chemical Biology, or related field.
2+ years hands-on experience in biophysics, bioconjugation, protein labeling, or a combination thereof.
Direct knowledge in assay development and utilizing SPR/BLI (e.g. Biacore or Octet) or LCMS technologies (e.g. QTOF or Orbitrap)
Experience in method or assay development utilizing a variety of LCMS technology (e.g. QTOF or Orbitrap).
Working knowledge of fluorescent based method or assay development (e.g. FP, FRET, etc).
Working knowledge in assay development and utilizing SPR/BLI (e.g. Biacore or Octet).
Excellent interpersonal skills with the ability to communicate and interact well with colleagues at all levels.
Committed to staying current with the latest scientific breakthroughs in structure-based drug design and biophysical analysis.
Biochemist Biophysicist duties
Work closely with senior scientists to accomplish team objectives and research milestones.
Contribute to the development and optimization of conjugation schemes to achieve the required product specifications.
Commit to producing and maintaining the highest standard of quality in antibody-conjugate productions.
Perform the following bioconjugation procedures; 1) Antibody and recombinant protein isolation and purification, 2) Purification of antibodies and conjugates using various liquid chromatography methods (IEX, SEC, HIC); 3) Antibody and conjugate validation via various functional tests, 4) Biophysical characterization of proteins and conjugates (e.g., UV/VIS spectrophotometry, DLS, SEC-MALS, native mass-spectrometry Tm or Tagg determination).
Characterize protein-ligand and protein-protein interactions by a variety of methods including but not limited to; Intact protein and peptide-based mass spectrometry, native mass spectrometry, fluorescence spectroscopy, SPR, BLI, and DSF.
